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Porphyrin‐linked oligonucleotides
Author(s) -
Frolova E.I.,
Ivanova E.M.,
Zarytova V.F.,
Abramova T.V.,
Vlassov V.V.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81129-c
Subject(s) - oligonucleotide , porphyrin , hemin , chemistry , adduct , piperidine , covalent bond , dna , cleavage (geology) , nucleotide , combinatorial chemistry , stereochemistry , derivative (finance) , sequence (biology) , biochemistry , organic chemistry , biology , enzyme , gene , heme , paleontology , fracture (geology) , financial economics , economics
Oligonucleotide derivatives bearing hemin and deuterohemin groups were synthesized. The derivatives efficiently react with the complementary nucleotide sequence in ssDNA forming covalent adducts and piperidine‐labile sites. In the case of the deuterohemin derivative, some direct cleavage of the target DNA occurs.