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Norepinephrine evokes a marked Mg 2+ efflux from liver cells
Author(s) -
Romani A.,
Scarpa A.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81113-3
Subject(s) - efflux , endocrinology , medicine , vasopressin , forskolin , chemistry , norepinephrine , carbachol , receptor , cytosol , adrenergic , adrenergic receptor , biology , biochemistry , enzyme , dopamine
The addition of norepinephrine to perfused rat livers and to collagenase isolated hepatocytes induced a marked and dose‐dependent magnesium efflux. The addition of β‐adrenergic receptor antagonists, but not α‐antagonists, completely blocked the Mg 2+ efflux. The Mg 2+ efflux could also be induced by forskolin and by permeable cAMP analogues. By contrast, the addition of carbachol or vasopressin induced a Mg 2+ influx into isolated hepatocytes. These results indicate that a significant Mg 2+ efflux from liver cells can be induced through the β‐adrenergic receptors and that it is mediated through the cytosolic cAMP levels.