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Regulation of the Na + ‐K + pump activity and estimation of the reserve capacity in intact rat peritoneal mast cells
Author(s) -
Knudsen T.,
Johansen T.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81105-w
Subject(s) - potassium , extracellular , sodium , chemistry , intracellular , biophysics , extracellular fluid , stimulation , membrane , endocrinology , biochemistry , biology , organic chemistry
Evidence is provided that regulation of the Na + ‐K + pump activity in rat peritoneal mast cells occurs mainly through stimulation of the pump from inside the plasma membrane by sodium. It is demonstrated that there is a large reserve capacity for the exchange of intracellular sodium with extracellular potassium in these cells. The maximal pump activity was estimated to be 3230cells per min and K m for extracellular potassium was 1.5 mM.