Premium
Hydrophobie cluster analysis reveals duplication in the external structure of human α‐interferon receptor and homology with γ‐interferon receptor external domain
Author(s) -
Gaboriaud Christine,
Uzé Gilles,
Lutfalla Georges,
Mogensen Knud
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81103-u
Subject(s) - receptor , interferon , biology , alpha interferon , homology (biology) , genetics , amino acid
Evidence is presented, based on sequence comparison according to Hydrophobic Cluster Analysis, of a structural and evolutionary relationship between the human α/β‐interferon receptor and the human and mouse γ‐interferon receptor. These results predict that the human α/β‐interferon receptor extracellular part is organised in two homologous subdomains connected by a proline linker. They also predict that both subdomains present some homologies to the external domain of mouse and human γ interferon receptor.