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Partial hepatectomy and mediators of inflammation decrease the expression of liver α 2 ‐HS glycoprotein gene in rats
Author(s) -
Daveau M.,
Davrinche C.,
Djelassi N.,
Lemetayer J.,
Julen N.,
Hiron M.,
Arnaud P.,
Lebreton J.P.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81055-s
Subject(s) - glycoprotein , inflammation , gene expression , gene , hepatectomy , chemistry , medicine , microbiology and biotechnology , endocrinology , biology , biochemistry , surgery , resection
Liver mRNA levels of two acute phase reactant (APR) proteins, α 2 ‐HS glycoprotein (a major negative APR) and α 1 ,‐acid glycoprotein (a major positive APR) were measured in male rats at different times after the administration of turpentine, of tumor necrosis factor, or following partial hepatectomy. In every case, a marked decrease in mRNA levels of α 2 HS glycoprotein was observed which reached a maximum at 24 h. A concomitant increase of α 1 ,‐acid glycoprotein mRNA levels was observed under the same conditions. These results indicate that the decreased levels of α 2 ‐HS glycoprotein induced by the acute‐phase response following inflammatory mediators and partial hepatectomy are due to a down‐regulation of the gene expression of this protein in rat liver.