Premium
The biological activity of retinoids in melanoma cells
Author(s) -
Redfern Christopher F.F.,
Daly Ann K.,
Latham Julie A.E.,
Todd Carole
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81041-l
Subject(s) - melanoma , chemistry , biological activity , cancer research , dermatology , medicine , biochemistry , in vitro
The expression of mRNA for retinoic acid receptor beta (RAR‐β was induced by all trans ‐retinoic acid in murine S91 melanoma cells. The induction of RAR‐β was dose‐dependent, rapid and insensitive to cycloheximide. Both 13‐ cis ‐retinoic acid and 3,4‐didehydro‐ all trans ‐retinoic acid also induced expression of RAR‐β but were only effective at concentrations 100‐fold greater than all trans ‐retinoic acid. The expression of RAR‐α and RAR‐γ was unaffected by retinoic acid.