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NADPH:O 2 oxidoreductase of human eosinophils in the cell‐free system
Author(s) -
Bolscher Ben G.J.M.,
Koenderman Leo,
Tool Anton T.J.,
Stokman Petra M.,
Roos Dirk
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81025-j
Subject(s) - chronic granulomatous disease , nadph oxidase , enzyme , eosinophil , chemistry , oxidoreductase , oxidase test , cell , immunology , biochemistry , microbiology and biotechnology , biology , asthma
The NADPH oxidase of human eosinophils, measured in the cell‐free system, shows the same characteristics as the enzyme from human neutrophils. All proteins required for activity of the enzyme are expressed in eosinophils at a higher level than in neutrophils. Eosinophils isolated from patients with chronic granulomatous disease show the same molecular defects as the neutrophils fom these patients.