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Arachidonic acid epoxygenase
Author(s) -
Karara Armando,
Dishman Elizabeth,
Jacobson Harry,
Falck J.R.,
Capdevila Jorge H.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81014-f
Subject(s) - epoxygenase , arachidonic acid , chemistry , medicine , biochemistry , enzyme
Mass spectral and Chromatographic analysis demonstrates the presence of 14,15‐, 11,12‐ and 8,9‐epoxyeicosatrienoic acids (44%, 33% and 23% of the total, respectively) in human kidney cortex. Chiral analysis of the human renal expoxyeicosatrienoic acids shows the formation of 8,9‐, 11,12‐ and 14,15‐epoxyeicosatrienoic acids in a 1:1, 4:1 and 2:1 ratio of antipodes, respectively. These results demonstrate the biosynthetic origin of the human kidney 11,12‐ and 14,15‐epoxyeicosatrienoic acids and suggest a role for renal cytochrome P‐450 in the bioactivation of endogenous pools of arachidonic acid.