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Involvement of external calcium in the release of arachidonic acid by mouse peritoneal macrophages
Author(s) -
Fernández Belén,
Balsinde Jesús
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80984-q
Subject(s) - arachidonic acid , extracellular , calcium , chemistry , biochemistry , microbiology and biotechnology , biophysics , biology , enzyme , organic chemistry
The present investigation was undertaken to study the potential role of extracellular calcium on the release of arachidonic acid from mouse peritoneal macrophages. Both in phorbol ester‐treated and in Ca 2+ ‐depleted cells, a rapid release of arachidonic acid was seen in direct response to added Ca 2+ . The response was directly dependent on the extracellular Ca 2+ concentration, with a Ca 2+ threshold of 100 nM. These results support the notion that arachidonic acid release in macrophages is functionally coupled to influx of external calcium.