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G Protein control of inositol lipids in intact vascular smooth muscle
Author(s) -
LaBelle Edward F.,
Murray Bonnie M.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80980-w
Subject(s) - gtp' , inositol , vascular smooth muscle , norepinephrine , medicine , pertussis toxin , g protein , endocrinology , egta , agonist , chemistry , biology , smooth muscle , biochemistry , receptor , calcium , enzyme , dopamine
Agonist‐induced PIP 2 , breakdown has been demonstrated in penneabilized vascular smooth muscle and shown to depend on a G protein. Segments of rat tail artery were permeabilized with ATP and EGTA after prelabeling with [ 3 H]inositol. Norepinephrine and GTPγS were both able to increase levels of IP, IP 2 , and IP 3 in the segments. The effects of both norepinephrine and GTPγS on the segments was non‐additive. Aluminum fluoride also increased inositol phosphates in intact segments and norepinephrine‐stimulated increases in IP, IP 2 , and IP 3 were insensitive to pertussis toxin.