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Flufenamic acid, mefenamic acid and niflumic acid inhibit single nonselective cation channels in the rat exocrine pancreas
Author(s) -
Gögelein H.,
Dahlem D.,
Englert H.C.,
Lang H.J.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80977-q
Subject(s) - niflumic acid , flufenamic acid , mefenamic acid , chemistry , pharmacology , biochemistry , chromatography , medicine
The non‐steroidal anti‐inflammatory drugs, flufenamic acid, mefenamic acid and niflumic acid, block Ca 2+ ‐activated non‐selective cation channels in inside‐out patches from the basolateral membrane of rat exocrine pancreatic cells. Half‐maximal inhibition was about 10 μM for flufenamic acid and mefenamic acid, whereas niflumic acid was less potent (IC 50 about 50 μM). Indomethacin, aspirin, diltiazem and ibuprofen (100μM) had not effect. It is concluded that the inhibitory effect of flufenamate, mefenamate and niflumate is dependent on the specific structure, consisting of two phenyl rings linked by an amino bridge.