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Exercise training increases glucose transporter protein GLUT‐4 in skeletal muscle of obese Zucker ( fa/fa ) rats
Author(s) -
Friedman Jacob E.,
Sherman William M.,
Reed Michael J.,
Eiton Charles W.,
Dohm G.Lynis
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80960-q
Subject(s) - glucose transporter , medicine , endocrinology , skeletal muscle , endurance training , insulin resistance , gastrocnemius muscle , insulin , glucose uptake
The present study examined the level of GLUT‐4 glucose transporter protein in gastrocnemius muscles of 36 week old genetically obese Zucker ( fa/fa ) rats and their lean ( Fa/‐ ) littermates, and in obese Zucker rats following 18 or 30 weeks of treadmill exercise training. Despite skeletal muscle insulin resistance, the level of GLUT‐4 glucose transporter protein was similar in lean and obese Zucker rats. In contrast, exercise training increased GLUT‐4 protein levels by 1.7 and 2.3 fold above sedentary obese rats. These findings suggest endurance training stimulates expression of skeletal muscle GLUT‐4 protein which may be responsible for the previously observed increase in insulin sensitivity with training.