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Acetylcholine receptor gene expression in experimental autoimmune myasthenia gravis
Author(s) -
Asher Orna,
Neumann Drorit,
Witzemann Veit,
Fuchs Sara
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80932-9
Subject(s) - myasthenia gravis , acetylcholine receptor , denervation , acetylcholine , gene expression , endocrinology , medicine , receptor , autoimmune disease , protein subunit , gene , biology , neuromuscular junction , immunology , microbiology and biotechnology , antibody , biochemistry , neuroscience
Acetylcholine receptor (AChR) gene expression was analyzed in experimental autoimmune myasthenia gravis (EAMG) in rabbits, rats and mice. An increase in AChR transcripts was demonstrated to be exclusively associated with myasthénie symptoms and with a severe loss in membrane AChR. An increase of α‐, β‐, ϵ‐, and δ‐subunit specific mRNAs (5.2‐, 1.6‐, 3.2‐ and 3.7‐fold, respectively), which code for the adult type of AChR (α 2 βϵδ) was observed in EAMG in rats. The γ‐subunit transcript was not detectable in myasthenie or healthy rats. It appears that the regulatory control of AChR gene expression in EAMG is different from that observed upon denervation.