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Growth factor‐induced release of a glycosyl‐phosphatidylinositol (GPI)‐linked protein from the HEp‐2 human carcinoma cell line
Author(s) -
Roberts Julia M.,
Kenton Paul,
Johnson Peter M.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80927-b
Subject(s) - phosphatidylinositol , cell culture , chemistry , growth factor , biochemistry , biology , phosphorylation , genetics , receptor
The release of a GPI‐linked oncofetal protein (PLAP) from HEp‐2 cells has been studied as an indicator of endogenous PI‐specific PLC activation. A non‐hydrolysable GTP analogue, EGF and insulin all produced a dose‐dependent release of PLAP from these cells. This indicates that an increase in PLC activity following either growth factor binding or G protein activation may cause cellular release of PLAP.