Premium
Induction of Mn 2+ /H + antiport in chicken erythrocytes by intracellular Mg 2+ and Mn 2+
Author(s) -
Günther T.,
Vormann J.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80882-j
Subject(s) - radiochemistry , antiporter , chemistry , intracellular , physics , membrane , biochemistry
Chicken erythrocytes preloaded with Mg 2+ exchange one extracellular Mn 2+ fo two intracellular H + . Chicken erythrocytes preloaded with Mn 2+ alone or with Mg 2+ plus Mn 2+ performed efflux of Mn 2+ , which was higher at pH 6 than at pH 7.4, indicating reversibility of Mn 2+ /H + antiport. Mn 2+ /H + antiport was not inhibited by 1 mM KCN plus 1 mM iodoacetic acid or 1 mM amiloride. Mn 2+ influx was activated by anions. Mn 2+ efflux via Mn 2+ /H + antiport was inhibited by competition between H + and K + .