Premium
Synthesis and secretion of Alzheimer amyloid βA4 precursor protein by stimulated human peripheral blood leucocytes
Author(s) -
Mönning Ursula,
König Gerhard,
Prior Reinhard,
Mechler Hans,
Schreiter-Gasser Ursula,
Masters Colin L.,
Beyreuther Konrad
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80861-c
Subject(s) - secretion , peripheral blood mononuclear cell , amyloid precursor protein , peripheral blood , immunology , receptor , secretory protein , alzheimer's disease , chemistry , biology , endocrinology , microbiology and biotechnology , medicine , biochemistry , disease , in vitro
Alzheimer amyloid precursor proteins (APP) are actively secreted by stimulated human peripheral mononuclear blood leucocytes (PMBLs). Induction of APP transcription, translation and secretion was observed with several T cell mitogens but was highest with phytohemagglutinin. The time course of induction is similar to that reported for IL‐2 and IL‐2 receptor. We suggest that APP may play an important role in the construction of the immunological network and the differentiation of T cells.