Premium
PCR amplification of CGRP II mRNA
Author(s) -
Lasmoles F.,
Minvielle S.,
Cohen R.,
Guliana J.M.,
Delehaye M.C.,
Segond N.,
Calmettes C.,
Milhaud G.,
Moukhtar M.S.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80856-e
Subject(s) - calcitonin gene related peptide , calcitonin , messenger rna , medullary carcinoma , thyroid carcinoma , multiple endocrine neoplasia , thyroid , endocrinology , medicine , gene , microbiology and biotechnology , chemistry , biology , receptor , neuropeptide , biochemistry
Two genes code for calcitonin gene‐related peptides (CGRPs). One expresses by tissue‐specific alternate splicing calcitonin and CGRP I mRNAs, the other CGRP II mRNA. Calcitonin is the marker of sporadic or hereditary human medullary thyroid carcinoma (MTC). CGRP II expression is not well established in normal or tumoral thyroid. After amplification by polymerase chain reaction, CGRP I and II mRNAs were detected in six cases of MTC associated with other endocrine neoplasia (MEN IIa) and in two cases of isolated MTC. CGRP I was detected in all non‐C cell tumoral thyroids (6 samples), CGRP II was barely detectable in three out of six cases. CGRP II could be a specific tumoral marker of MTC.