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Nucleotide sequence of the Yersinia pestis gene encoding F1 antigen and the primary structure of the protein
Author(s) -
Galyov E.E.,
Smirnov O.Yu.,
Karlishev A.V.,
Volkovoy K.I.,
Denesyuk A.I.,
Nazimov I.V.,
Rubtsov K.S.,
Abramov V.M.,
Dalvadyanz S.M.,
Zav'yalov V.P.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80852-a
Subject(s) - yersinia pestis , gene , peptide sequence , signal peptide , nucleic acid sequence , plasmid , protein primary structure , biology , microbiology and biotechnology , yersinia , sequence (biology) , amino acid , antigen , genetics , bacteria , virulence
The plasmid‐located gene cafl encoding the capsular antigen fraction 1 (F1) of Yersinia pestis was cloned and sequenced. The gene codes for a 170 amino acid peptide with a deduced M r of 17.6 kDa. The signal peptide sequence was highly homologous to the E. coli consensus signal sequence. The F1 was assumed to have β‐sheet structure for the most part. The region located between amino acids 100 and 150 was suggested to contain putative antigenic determinants and to stimulate T cells.