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Acetyl‐L‐carnitine increases cytochrome oxidase subunit I mRNA content in hypothyroid rat liver
Author(s) -
Gadaleta M.N.,
Petruzzella V.,
Fracasso F.,
Fernandez-Silva P.,
Cantatore P.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80841-6
Subject(s) - carnitine , messenger rna , cytochrome c oxidase , endocrinology , mitochondrion , protein subunit , medicine , oxidase test , chemistry , microsome , biochemistry , enzyme , biology , gene
The effect of acetyl‐L‐carnitine on the quantity of the messenger RNA for the subunit I of cytoehrome oxidase in the liver mitochondria of hypothyroid rat was measured by Northern blot and solution hybridization. Three hours after pre‐treatment of hypothyroid rat with acetyl‐L‐carnitine, the level of the transcript increased strongly. This effect was also obtained when acetyl‐L‐carnitine was administered to T 3 pre‐treated hypothyroid rats. These results add further evidence to the suggestion that acetyl‐L‐camitine is able to stimulate mitochondrial transcription under altered metabolic conditions.