Premium
Class IV mammalian alcohol dehydrogenase
Author(s) -
Parés Xavier,
Moreno Alberto,
Cederlund Ella,
Höög Jan-Olov,
Jörnvall Jans
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80822-z
Subject(s) - alcohol dehydrogenase , enzyme , dehydrogenase , alcohol , biochemistry , biology , lactate dehydrogenase , chemistry
The stomach form of alcohol dehydrogenase has been structurally evaluated by peptide analysis covering six separate regions of the rat enzyme. Overall, this new structure diners widely (32–40% residue differences) from the structures of three classes of alcohol dehydrogenase characterized before from the same species. Consequently, this novel enzyme constitutes a true fourth class of mammalian alcohol dehydrogenase. In particular, differences are extensive also towards class II, although enzymatic and physicochemical properties initially suggested overall similarities with class II. The new structure establishes the presence of one further alcohol dehydrogenase mammalian gene, extends the enzyme family derived from repeated gene duplications, and confirms tissue‐specific expressions.