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Neurokinin‐immunoreactivity in human neuroblastomas
Author(s) -
McGregor Gerard P.,
Gaedicke Gerhard,
Voigt Karlheinz
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80814-y
Subject(s) - neuropeptide , neurokinin a , substance p , radioimmunoassay , biology , gene , neuropeptide y receptor , medicine , peripheral nervous system , endocrinology , central nervous system , genetics , receptor
Factors regulating differentiation of the peripheral nervous system (PNS) have been widely studied in neuroblastomas which are tumors of the PNS. Five neuroblastomas were investigated for their content of tachykinin neuropeptides, which arise from two distinct genes which appear differentially expressed in the PNS. Radioimmunoassay and column chromatography revealed large amounts of neurokinin B in three of these tumors and the absence of substance P, neurokinin A, neuropeptide K and neuropeptide γ from all five tumors. This suggests that neuroblastomas can selectively express the preprotachykinin (PPT) II gene and that they may be valuable for investigating the factors involved in the regulation of these two structurally‐related neuropeptide genes.