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Desferrioxamine as a lipid chain‐breaking antioxidant in sickle erythrocyte membranes
Author(s) -
Hartley Andrew,
Davies Michael,
Rice-Evans Catherine
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80786-i
Subject(s) - chemistry , antioxidant , hydrogen peroxide , myoglobin , radical , chelation , peroxidase , superoxide , ferric , biochemistry , membrane , mechanism of action , enzyme , organic chemistry , in vitro
The mechanism of action of desferrioxamine in the inhibition of the catalysis of iron‐induced oxidative damage has been ascribed to its ability to chelate available ferric ion ( K b = 10 31 ). However, recent work has proposed that the trihydroxamate moiety of desferrioxamine can also be involved in electron transfer reactions involving the Superoxide radical, peroxidase/hydrogen peroxide mixtures and ferryl myoglobin radicals. In this study we report evidence for the ability of desferrioxamine to inhibit peroxidative damage to pathological membranes with which non‐haem iron is associated through a mechanism of action as a lipid chain breaking antioxidant, independently of its iron chelating properties.