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Replication‐linked histone acetylation in rat liver tissue is sensitive to alkylating agents
Author(s) -
Talasz Heribert,
Weiss Günter,
Puschendorf Bernd
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80785-h
Subject(s) - acetylation , histone , thymidine , histone acetyltransferase , proliferating cell nuclear antigen , biology , microbiology and biotechnology , chemistry , biochemistry , dna , gene
The effect of alkylating agents on histone acetyltransferase (EC 2.3.1.48) activity and thymidine incorporation was investigated in benign and malignant proliferating rat liver tissue and compared with the effect in normal non‐proliferating rat liver tissue. In both, benign and malignant proliferating tissue, but not in quiescent tissue, the histone acetylation is depressed by alkylating agents and this depression correlates with the inhibition of the thymidine incorporation. This effect suggests that the depression of the replication associated histone acetylation may be an important factor for the antiproliferative activity of alkylating agents.