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Expression of retinoic acid receptor genes in neural crest‐derived cells during mouse facial development
Author(s) -
Osumi-Yamashita Noriko,
Noji Sumihare,
Nohno Tsutomu,
Koyama Eiki,
Doi Hirofumi,
Eto Kazuhiro,
Taniguchi Shigehiko
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80767-d
Subject(s) - retinoic acid , neural crest , retinoic acid receptor beta , retinoic acid receptor , gene , retinoic acid receptor gamma , microbiology and biotechnology , biology , receptor , retinoic acid inducible orphan g protein coupled receptor , neural development , chemistry , genetics
Retinoic acid (RA) is known as a teratogen that induces abnormalities in facial structures which are made up mainly of neural crest‐derived mesenchyme. We investigated expression patterns of RA receptor (RAR) genes (subtypes α, β, γ) during mouse facial development. The expression of the rarβ gene is specific for the mesenchyme around developing eyes and nose, whereas the RARγ gene is expressed in the mesenchyme differentiating to facial cartilages and bones. In contrast, the RARα gene is expressed weakly and uniformly over the facial region. These results suggest that crucial roles of endogenous RA in facial development depend on differential functions of the RAR subtypes.