Premium
Differential regulation of prostatic protein kinase C isozymes by androgens
Author(s) -
Goueli Said A.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80762-8
Subject(s) - isozyme , protein kinase c , gene isoform , endocrinology , medicine , androgen , biology , enzyme , cytosol , castration , chemistry , prostate , alpha (finance) , biochemistry , hormone , gene , cancer , construct validity , nursing , patient satisfaction
Multiple isozymes of Ca 2+ /phospholipid‐dependent protein kinase (PKC) were isolated from the rat ventral prostate. The enzyme exists mainly as type II (β), and type III (α) forms, and it is possible that type II isozyme may comprise the subspecies β 1 and β 2 . The total and specific activities of prostatic PKC isoforms were reduced in castrated animals; this decrease was specific since administration of androgens to castrated animals reversed such a decline. Also, there was a differential response to androgen deprivation so that type III isozyme declined at a faster rate than that of type II. Thus, our studies show for the first time that PKC of the rat ventral prostate comprises multiple isozymes, and that the activity of these various forms are differentially regulated by androgens.