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Chromosomal localization of the mouse genes coding for α2, α3, α4 and β2 subunits of neuronal nicotinic acetylcholine receptor
Author(s) -
Bessis Alain,
Simon-Chazottes Dominique,
Devillers-Thiéry Anne,
Guénet Jean-Louis,
Changeux Jean-Pierre
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80761-7
Subject(s) - nicotinic acetylcholine receptor , acetylcholine receptor , biology , gene , protein subunit , alpha 4 beta 2 nicotinic receptor , ganglion type nicotinic receptor , genetics , microbiology and biotechnology , nicotinic agonist , coding region , receptor
The chromosomal localization of four neuronal nicotinic acetylcholine receptor subunit genes was performed by following the mendelian segregation of their corresponding alleles in backcrosses involving the mouse species Mus spretus and the laboratory strains C57BL/6 or BALB/c. A similar analysis previously performed with muscle nicotinic acetylcholine receptor subunits revealed that the genes coding for the α and β subunits are respectively located on chromosome 2 and 11, whereas the γ and δ subunit coding genes are linked and located on mouse chromosome 1. In this study, we show that the genes coding for the neuronal nicotinic acetylcholine receptor α2, α3 and β2 subunits are dispersed on three different mouse chromosomes, viz . 14, 9 and 3 respectively. Moreover, the α4 subunit gene is located on chromosome 2 but is not genetically linked to the α1 subunit gene.