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Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus
Author(s) -
Hidaka Yuji,
Sato Kazuki,
Nakamura Hideshi,
Kobayashi Jun'ichi,
Ohizumi Yasushi,
Shimonishi Yasutsugu
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80756-9
Subject(s) - disulfide bond , peptide , neurotoxin , conus , chemistry , intramolecular force , conotoxin , venom , stereochemistry , biophysics , biochemistry , biology , anatomy
The three intramolecular disulfide linkages of geographutoxin I, a peptidic neurotoxin isolated from the venom of the marine snail Conus geographus , were examined by a novel method for determination of the positions of disulfide linkages in peptides [(1989) Bull. Chem. Soc. Jp. 62, 1986–1994]. The disulfide bridges were found to be between Cys 3 and Cys 15 , Cys 4 and Cys 20 , and Cys 10 and Cys 21 , indicating that geographutoxin I has a rigid conformation consisting of three loops stabilized by these three disulfide linkages.