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Regional expression of a MCD‐peptide and dendrotoxin I‐sensitive voltage‐dependent potassium channel in rat brain
Author(s) -
Séquier Jean-Marc,
Brennand John,
Barhanin Jacques,
Lazdunski Michel
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80729-3
Subject(s) - globus pallidus , basal ganglia , potassium channel , cerebellum , putamen , neuroscience , peptide , in situ hybridization , biology , chemistry , central nervous system , microbiology and biotechnology , biophysics , biochemistry , messenger rna , gene
In situ hybridization histochemistry has been used to analyze the regional expression of a class of voltage‐dependent K + channel that is sensitive to two polypeptide toxins (MCD peptide and dendrotoxin I) that produce spectacular effects on brain function. A heterogeneous expression of this K + channel was observed throughout the brain. High naRNA contents were observed in the granule cells of the gyrus dentatus as well as in pyramidal cells of the Ammon hom (CA3 > CA1) and in the cerebellum. Conversely, low levels of expression were found in basal ganglia (caudate putamen, globus pallidus, and ventral pallidum).