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Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene
Author(s) -
Kawajiri Kaname,
Nakachi Kei,
Imai Kazue,
Yoshii Akira,
Shinoda Nahomi,
Watanabe Junko
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80721-t
Subject(s) - genotype , restriction fragment length polymorphism , lung cancer , allele , biology , genetics , heterozygote advantage , gene , microbiology and biotechnology , allele frequency , restriction enzyme , population , medicine , environmental health
A good correlation was observed between enhanced lung cancer risk and restriction fragment length polymorphisms (RFLPs) of the P450IA1 gene with the restriction enzyme Msp I. Genotype frequencies of 0.49 for the predominant homozygote, 0.40 for the heterozygote, and 0.11 for the homozygous rare allele were observed in a healthy population. Among lung cancer patients, the frequency of homozygous rare allele of P450IA1 gene was found to be about 3‐fold higher than that among healthy population, and this difference was statistically significant. This is the first report to identify the genetically high risk individuals to lung cancer at the gene level.