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A common mechanism of transcriptional activation by the three positive regulators, VirG, PhoB, and OmpR
Author(s) -
Aoyama Takashi,
Oka Atsuhiro
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80691-b
Subject(s) - regulon , transcriptional regulation , gene , biology , regulation of gene expression , operon , genetics , mechanism (biology) , promoter , regulator , microbiology and biotechnology , transcription factor , gene expression , escherichia coli , philosophy , epistemology
VirG, PhoB, and OmpR are positive regulators of the virulence, phosphate, and osmolarity regulons, respectively. Their target genes are attended with one or more significant blocks of similar 6‐bp sequences in their regulatory regions. The distance between the block(s) and transcriptional start site varies with the target genes, but the blocks are located in a similar manner phase‐specific to the promoter sequences. On the basis of these facts, we offer a novel model of transcriptional activation common to these regulators.