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Reactions of iron(II) nucleotide complexes with hydrogen peroxide
Author(s) -
Rush J.D.,
Maskos Z.,
Koppenol W.H.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80651-x
Subject(s) - chemistry , hydrogen peroxide , pyrophosphate , ferrous , reaction rate constant , ferric , inorganic chemistry , nucleotide , medicinal chemistry , kinetics , oxidative phosphorylation , photochemistry , enzyme , organic chemistry , biochemistry , physics , quantum mechanics , gene
The rate constants for the reactions of hydrogen peroxide with ferrous complexes of ATP, ADP, UTP, citrate and pyrophosphate were measured at pH 7.2. These ligands are potential chelators of iron(II) in the low‐molecular weight iron pool that may catalyze oxidative degradation of tissues. The second‐order rate constants range from 5.5 × 10 3 M −1 s −1 (UTP) to 1 × 10 5 M −1 s −1 (pyrophosphate) at pH 7.2. The kinetic dependences of the ATP reaction are consistent with a mechanism involving a ‘ferryl’ (Fe IV ) transient which decays to the hydroxyl radical and ferric ATP.