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Species‐specific Mn 2+ /Mg 2+ antiport from Mg 2+ ‐loaded erythrocytes
Author(s) -
Günther T.,
Vormann J.,
Cragoe E.J.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80633-t
Subject(s) - antiporter , amiloride , chemistry , extracellular , intracellular , ion transporter , nuclear chemistry , ion , medicinal chemistry , biochemistry , membrane , sodium , organic chemistry
Mg 2+ ‐loaded rat erythrocytes performed Mn + /Mg 2+ antiport, which was nonspecifically stimulated by anions and cations. Mn 2+ /Mg 2+ antiport was shown to operate via the Na + Mg 2+ antiporter because extracellular Na + and Mn 2+ inhibited the intracellular uptake of each other's ions competitively. Furthermore, Mn 2+ /Mg 2+ antiport and Na + /Mg 2+ antiport were identically inhibited by various amiloride derivatives. Na + /Mg 2+ antiport of chicken and human erythrocytes cannot perform Mn 2+ /Mg 2+ antiport although chicken erythrocytes took up more Mn 2+ than raterythrocytes.