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Phosphorylation of a bacterial activator protein, OmpR, by a protein kinase, EnvZ, stimulates the transcription of the ompF and ompC genes in Escherichia coli
Author(s) -
Aiba Hirofumi,
Mizuno Takeshi
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80626-t
Subject(s) - phosphorylation , bacterial outer membrane , escherichia coli , activator (genetics) , biology , transcription (linguistics) , gene , transcription factor , protein phosphorylation , protein kinase a , membrane protein , microbiology and biotechnology , biochemistry , linguistics , philosophy , membrane
The OmpR of Escherichia coli is a positive regulator specific for the ompF and ompC genes, which encode outer membrane proteins OmpF and OmpC, respectively. The EnvZ protein is a protein kinase which specifically phosphorylates the OmpR protein. In this study, the results of in vitro transcription experiments revealed that the phosphorylation of the OmpR protein by the EnvZ protein stimulates the transcription of both the ompF and ompC genes.