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A conserved cleavage‐site motif in chloroplast transit peptides
Author(s) -
Gavel Ylva,
von Heijne Gunnar
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80614-o
Subject(s) - cleavage (geology) , transit peptide , motif (music) , chloroplast , biology , chemistry , computational biology , biochemistry , gene , physics , paleontology , plastid , fracture (geology) , acoustics
A collection of 32 stroma‐targeting chloroplast transit peptides with known cleavage sites have been analysed in terms of amino acid preferences in the vicinity of the processing site. A loosely conserved consensus motif (Val/Ile)‐X‐(Ala/Cys)↓Ala is found in the majority of the transit peptides. About 30% of the sequences have a perfect match to the consensus. When such a match is found, there is a 90% probability that it specifies the correct cleavage site.