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One of the endothelin gene family, endothelin 3 gene, is expressed in the placenta
Author(s) -
Onda Haruo,
Ohkubo Shoichi,
Ogi Kazuhiro,
Kosaka Takuo,
Kimura Chiharu,
Matsumoto Hirokazu,
Suzuki Nobuhiro,
Fujino Masahiko
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80583-5
Subject(s) - gene , placenta , endothelin 1 , endothelin receptor , gene family , endothelin 3 , endothelins , biology , genetics , endocrinology , medicine , gene expression , pregnancy , fetus , receptor
A cDNA encoding human endothelin 3 (ET‐3) precursor was cloned from a cDNA library from the placenta, and its nucleotide and deduced amino acid sequences were determined. This ET‐3 cDNA was found to contain 2.3 kb pairs and encode prepro‐ET‐3 protein consisting of 224 amino acid residues. The putative big‐ET‐3 seems to consist of 42 amino acid residues. Two of the intron insertion sites were determined with information from nucleotide sequences of the cloned genomic ET‐3 gene. This is the first direct evidence that the ET‐3 gene is transcribed and expressed in the placenta.