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Exercise modulates the insulin‐induced translocation of glucose transporters in rat skeletal muscle
Author(s) -
Douen Andre G.,
Ramlal Toolsie,
Cartee Gregory D.,
Klip Amira
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80566-2
Subject(s) - glucose transporter , insulin , medicine , endocrinology , glucose uptake , transporter , intracellular , skeletal muscle , chemistry , glut4 , biology , biochemistry , gene
Insulin and acute exercise (45 min of treadmill run) increased glucose uptake into perfused rat hindlimbs 5‐fold and 3.2‐fold, respectively. Following exercise, insulin treatment resulted in a further increase in glucose uptake. The subcellular distribution of the muscle glucose transporters GLUT‐1 and GLUT‐4 was determined in plasma membranes and intracellular membranes. Neither exercise nor exercise→ insulin treatment altered the distribution of GLUT‐1 transporters in these medmbrane fractions. In contrast, exercise, insulin and exercise→ insulin treatment caused comparable increases in GLUT‐4 transporters in the plasma membrane. The results suggest that exercise might limit insulin‐induced GLUT‐4 recruitment and that following exercise, insulin may alter the intrinsic activity of plasma membrane glucose transporters.