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The inhibition by pertussis and tetanus toxins of evoked catecholamine release from intact and permeabilized bovine adrenal chromaffin cells
Author(s) -
Bansal Mohinder K.,
Phillips John H.,
van Heyningen Simon
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80533-o
Subject(s) - pertussis toxin , catecholamine , toxin , chromaffin cell , secretion , endocrinology , medicine , chemistry , biology , adrenal medulla , g protein , biochemistry , receptor
Pertussis toxin stimulates both basal and nicotine‐evoked catecholamine secretion from intact bovine adrenal chromaffin cells, as well as Ca 2+ ‐evoked release from permeabilized cells. Tetanus toxin inhibits all these effects; it reduces the secretion of intact cells treated with pertussis toxin to the basal level, and decreases by about 50% Ca 2+ ‐evoked release from permeabilized cells whether or not previously stimulated by pertussis toxin.