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Reduction of nerve growth factor level in the brain of genetically ataxic mice (weaver, reeler)
Author(s) -
Matsui Kyoko,
Furukawa Shoei,
Shibasaki Hiroshi,
Kikuchi Tateki
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80511-g
Subject(s) - reeler , cerebrum , cerebellum , nerve growth factor , mutant , biology , purkinje cell , medicine , endocrinology , neuroscience , anatomy , central nervous system , biochemistry , gene , receptor
By a highly sensitive enzyme immunoassay we measured the level of nerve growth factor (NGF) in the cerebellum and cerebrum of the neurologically mutant mice, weaver, reeler and Purkinje cell degeneration (PCD). A significant decrease in NGF level was observed in both cerebellum and cerebrum of weaver and reeler mutants of either sex. However, there was no such difference between normals and mutants in the case of the PCD mice. These results show that weaver and reeler mice have abnormalities of NGF synthesis and/or degradation not only in the cerebellum but also in the cerebrum.