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Evidence for aggregation of endothelin 1 in water
Author(s) -
Bennes René,
Calas Bernard,
Chabrier Pierre-Etienne,
Demaille Jacques,
Heitz Frédéric
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80497-7
Subject(s) - chemistry , endothelin receptor , biophysics , biochemistry , biology , receptor
In this report it is shown by CD spectroscopy that endothelin 1, when dissolved in water, is able to present intermolecular interactions leading to formation of aggregates. Surface tension and conductivity measurements suggest that the aggregation occurs through formation of micelles with a CMC of about 2.2 × 10 −5 M.