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Nonthermal 60 Hz sinusoidal magnetic‐field exposure enhances 45 Ca 2+ uptake in rat thymocytes: dependence on mitogen activation
Author(s) -
Walleczek Jan,
Liburdy Robert P.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80396-z
Subject(s) - concanavalin a , chemistry , metabolism , biophysics , nuclear magnetic resonance , biology , biochemistry , physics , in vitro
The effect of a 60 Hz sinusoidal magnetic field of nonthermal intensity on Ca 2+ metabolism in rat thymic lymphocytes (thymocytes) was assessed in resting cells and in cells activated with the mitogen Concanavalin A (Con A). A 60 min exposure at 37°C to an induced electric field of 1.0 produced an average 2.7‐fold increase in Con A‐dependent 45 Ca 2+ ‐uptake compared to non‐exposed, isothermal control cells. In contrast, 45 Ca 2+ uptake remained unaltered during exposure of resting thymocytes. It was also found that thymocytes with a diminished ability to mobilize Ca 2+ in response to Con A were most sensitive to the 60 Hz magnetic field. Although the precise mechanism of field interaction is at present unknown, modulation of Ca 2+ metabolism during cell activation may represent a common pathway for field coupling to cellular systems.