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Synthetic sialyl glycolipids (sialo‐cholesterol and sialo‐diglyceride) induce granulocytic differentiation of human myelogenous leukemia cell line HL‐60
Author(s) -
Saito Masaki,
Nojiri Hisao,
Ogino Hidetoshi,
Yuo Akira,
Ogura Haruo,
Itoh Masayoshi,
Tornita Kenkichi,
Ogawa Tomoya,
Nagai Yoshitaka,
Kitagawa Seiichi
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80378-v
Subject(s) - chemistry , glycolipid , cellular differentiation , cell culture , diglyceride , biochemistry , fucosyltransferase , microbiology and biotechnology , enzyme , biology , genetics , gene
When HL‐60 cells were cultivated with synthetic sialyl glycolipids, sialo‐cholesterol and sialo‐diglyceride, the cells were found to be differentiated into mature granulocytes on morphological and functional criteria. The differentiation of cells was accompanied by inhibition of cell proliferation. The differentiation‐inducing activity of sialo‐cholesterol was greater than that of sialo‐diglyceride on a molar basis, and the α‐anomer of each compound was more potent than the β‐anomer, suggesting that the stereospecific structure of the compounds is important for the differentiation‐inducing activity.