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Molecular cloning of a novel G protein‐coupled receptor that may belong to the neuropeptide receptor family
Author(s) -
Eva Carola,
Keinänen Kari,
Monyer Hanna,
Seeburg Peter,
Sprengel Rolf
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80377-u
Subject(s) - 5 ht5a receptor , biology , g protein coupled receptor , forebrain , complementary dna , receptor , transmembrane protein , transmembrane domain , gabbr1 , microbiology and biotechnology , enzyme linked receptor , cdna library , genetics , neuroscience , gene , protease activated receptor 2 , central nervous system
A novel cDNA encoding a putative G protein‐coupled receptor was isolated from a rat forebrain cDNA library by homology screening. Sequence comparison demonstrates that the encoded polypeptide containing seven transmembrane domains shows highest homology with tachykinin receptors, particularly in the transmembrane domains and the first intracellular loop. The mRNA for this new receptor seems specifically expressed in brain and is prominently localized in specific nuclei of the rat brain, including thalamus, cerebral cortex and hippocampus. We speculate that a neuropeptide may be the natural ligand of this novel G protein‐coupled receptor.