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On the role of insulin in regulation of adenosine deaminase activity in rat tissues
Author(s) -
Rutkiewicz Joanna,
Górski Jan
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80376-t
Subject(s) - adenosine deaminase , medicine , endocrinology , insulin , adenosine , streptozotocin , skeletal muscle , diabetes mellitus , chemistry , amp deaminase , biology
After administration of insulin adenosine deaminase activity was reduced in different skeletal muscle types, the heart and the liver. On the other hand profound reduction in the plasma insulin concentration (streptozotocin diabetes) resulted in elevation of the enzyme activity in the tissues. It is concluded that the local concentration of adenosine may be effected by the concentration of insulin in the plasma.