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Effects of D600 on hypoxic suppresssion of K + currents in isolated type I carotid body cells of the neonatal rat
Author(s) -
Peers C.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80366-q
Subject(s) - carotid body , chemistry , biophysics , endocrinology , medicine , microbiology and biotechnology , biology , carotid arteries
K + currents recorded from isolated type I carotid body cells were reversibly suppressed by hypoxia ( p O 2 25 Torr). Inhibition of Ca 2+ influx using high Mg 2+ , low Ca 2+ solutions abolished this effect, indicating hypoxia selectively inhibits the Ca 2+ ‐activa ted component of K + currents. The Ca 2+ channel blockers D600 and verapamil reversed the suppressive effects of hypoxia. These drugs also partially inhibited Ca 2+ ‐independent K + currents, but this effect was relieved by hypoxia, causing apparent reversal of hypoxic suppression of the K + currents seen under control conditions.