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One amino acid change in rat SMR1 polypeptide induces a 1 kDa difference in its apparent molecular mass determined by electrophoretic analysis
Author(s) -
Rosinski-Chupin Isabelle,
Rougeon François
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80310-f
Subject(s) - molecular mass , electrophoresis , amino acid , chemistry , significant difference , biochemistry , biology , medicine , enzyme
SMR1 is a male‐specific, 19 kDa, in vitro translation product of Wistar rat submaxillary glands, which may be the precursor of a small hormone resembling the TRH. In Sprague‐Dawley and Fischer rats, instead of SMR1, a male‐specific 18 kDa polypeptide may be found. We have cloned the cDNA encoding the 18 kDa polypeptide. We show that the 19 and the 18 kDa polypeptides have the same sequence except for one amino acid change.