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Decavanadate acts like an α‐adrenergic agonist in redistributing protein kinase C activity
Author(s) -
Gullapalli Sharada,
Kurup C.K.Ramakrishna,
Ramasarma T.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80296-u
Subject(s) - phenoxybenzamine , agonist , phenylephrine , propranolol , chemistry , protein kinase c , adrenergic agonist , cytosol , medicine , endocrinology , adrenergic , receptor , kinase , biochemistry , enzyme , biology , blood pressure
Perfusion of rat livers with polyvanadate, but not metavanadate, was found to increase in plasma membrane and decrease in cytosol protein kinase C activity, similar to that obtained with phenylephrine, an α‐adrenergic agonist. The effect was prevented by phenoxybenzamine, but not by propranolol implicating α‐adrenergic receptor activation. Comparison of crystal structures of decavanadate and nonadrenaline revealed the occurrence of a structural feature of O‐O‐O(N) with distances of 5.5 Å and 2.9 Å.