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Enhanced secretion of endothelin‐1 by elevated glucose levels from cultured bovine aortic endothelial cells
Author(s) -
Yamauchi Teruaki,
Ohnaka Keizo,
Takayanagi Ryoichi,
Umeda Fumio,
Nawata Hajime
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80276-o
Subject(s) - medicine , endocrinology , secretion , endothelin 1 , aldose reductase , endothelium , aldose reductase inhibitor , endothelin receptor , chemistry , in vitro , endothelial stem cell , diabetes mellitus , biology , biochemistry , receptor
We have investigated the effect of glucose on the release of endothelin‐1‐like immunoreactivity (ET‐l‐LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET‐1‐LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose‐induced ET‐1‐LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET‐1‐LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.