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The cell adhesion molecule Cell‐CAM 105 is an ecto‐ATPase and a member of the immunoglobulin superfamily
Author(s) -
Aurivillius Magnus,
Hansen Ole C.,
Lazrek Mohamed B.S.,
Bock Elisabeth,
Öbrink Björn
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80264-j
Subject(s) - immunoglobulin superfamily , cell adhesion , cell adhesion molecule , biochemistry , transmembrane protein , extracellular , atpase , immunoglobulin domain , trypsin , biology , antibody , cell , cell membrane , adhesion , microbiology and biotechnology , chemistry , enzyme , receptor , immunology , organic chemistry
Cell‐CAM 105 (C‐CAM), a cell adhesion molecule in rat hepatocytes, was digested with trypsin, and peptides were isolated and sequenced by Edman degradation. The sequences of 4 peptides agreed with different regions of rat liver ecto‐ATPase. Detailed biochemical analyses confirmed the identity between C‐CAM and the ecto‐ATPase. C‐CAM/ecto‐ATPase is a transmembrane protein having 4 immunoglobulin‐like domains in the extracellular portion, demonstrating membership of the immunoglobulin superfamily. The ATPase activity suggests that ATP might influence cell adhesion, which would explain the inhibitory effect of exogenously added ATP on adhesion of several cell types.