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The role of phospholipase A 2 in lipid peroxidation‐induced fall of membrane potential of rat liver mitochondria
Author(s) -
Gogvadze V.G.,
Brustovetsky N.N.,
Zhukova A.A.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80240-j
Subject(s) - lipid peroxidation , cumene hydroperoxide , mitochondrion , chemistry , membrane potential , phospholipase a2 , biochemistry , inner mitochondrial membrane , phospholipase a , phospholipase , organelle , membrane , biophysics , enzyme , biology , catalysis
Cumene hydroperoxide (230 μM)‐induced fall of the membrane potential takes place only in Ca 2+ ‐loaded mitochondria. Inhibitor of phospholipase A 2 , P ‐bromphenacyl bromide prevents uncoupling of mitochondria, having no effect on the accumulation of lipid peroxidation products.