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Time‐dependent inhibition of porcine kidney trehalase by aminosugars
Author(s) -
Salleh Hamzah Mohd.,
Honek John F.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)80229-c
Subject(s) - trehalase , chemistry , kidney , biochemistry , biology , enzyme , endocrinology
The inhibitory effects of various nitrogen‐containing sugars on porcine kidney trehalase were studied. Validamycin A, validoxylamine A and MDL 25637 were found to be potent, time‐dependent inhibitors of the enzyme in vitro. The validoxylamine A‐inhibited enzyme showed slow but reversible reactivation over time ( t= 1.2 h). To our knowledge, this is the first report of time‐dependent inhibition exhibited by either these particular amino‐sugars or a trehalase.